美高梅
美高梅
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川沙总部电话: +86 (21) 5859-1500
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Email:marketing@medicilon.com
信号转导和转录激活因子(signal transducer and activator of transcription, STAT)是一大类具有细胞质内信号转导和细胞核内转录激活双重作用的卵白，，，普遍保存于哺乳动物细胞中，，，介导多种细胞内信号通路。。 。
The signal transducer and activator of transcription (STAT) is a family of intracellular cytoplasmic transcription factors involved in many biological functions in mammalian signal transduction.
STAT3是一种在多种组织中表达的信号分子。。 。STAT3加入细胞增殖、分解、凋亡和炎症反应等多种生物学历程。。 。然而，，，STAT3在大大都人类癌症中变得太过激活，，，通常与不良的临床预后有关。。 。
Among them STAT3 is involved in cell proliferation,differentiation,apoptosis and inflammatory responses, and also STAT3-related signaling pathways are a barren over-activated in many types of cancer and are strongly associated with poor patient prognosis.
肿瘤微情形（TME）中肿瘤细胞内STAT3太过激活会介导一系列细胞外信号，，，增强肿瘤微情形的免疫炎症反应，，，驱动肿瘤细胞增殖、侵袭和转移，，，同时强烈抗肿瘤免疫反应并创立免疫抑制微情形。。 。
Excessive activation of STAT3 within tumor cells and other cells in the tumor microenvironment (TME) mediates a series of extracellular signals that enhances the immune inflammatory response in a TME, driving tumor cell proliferation, invasion, and metastasis, while strongly suppressing the anti-tumor immune response and creating an immunosuppressive microenvironment.
研究批注，，，一连激活的STAT3关于多种癌症是必不可少的，，，好比乳腺癌和结直肠癌，，，这使得STAT3成为理想的药物靶点。。 。
Studies have indicated that persistently activated STAT3 is indispensable for various cancers including breast cancer and coleractal cancer ,which makes it an ideal drug target.
美高梅可提供STAT3药物发明、CMC研究（API+制剂）、药效研究、PK研究、清静性评价等一站式研发效劳。。 。
Medicilon provides STAT3 drug discovery, CMC Research (API + formulation), pharmacodynamics research, PK study, safety evaluation and other services.
药物研发相关中心体产品推荐
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川沙总部
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